Code | CSB-YP761526HDAM |
MSDS | |
Size | $436 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
Matrix proteins are essential players in a wide range of biological activities, from forming mineralized tissues to helping viruses assemble and stabilize mRNA. They're particularly influential in guiding the process of biomineralization, where they control everything from how crystals form to their shape and structure [1]. When it comes to viruses, matrix proteins are key for putting together viral particles and are situated just beneath the viral membrane [2][3]. Studies have also shown that matrix proteins from certain viruses stick to viral nucleocapsids inside infected cells and virions [4]. Besides their viral duties, matrix proteins pitch in to stabilize mRNA. For instance, a protein called hnRNPA1, part of the nuclear matrix, does just that [5]. In the realm of bone, matrix proteins like SIBLING proteins play vital roles in mineralizing skeletal tissue and keeping bones healthy [6]. There's also a growing understanding of how matrix proteins contribute to heart health, with researchers identifying more and more of these proteins and unraveling their diverse functions in heart tissue [7].
References:
[1] J. Kong, C. Liu, T. Wang, D. Yang, Y. Yan, Y. Chenet al., "Cloning, characterization and functional analysis of an alveoline-like protein in the shell of pinctada fucata", Scientific Reports, vol. 8, no. 1, 2018. https://doi.org/10.1038/s41598-018-29743-6
[2] S. Scianimanico, "Membrane association induces a conformational change in the ebola virus matrix protein", The Embo Journal, vol. 19, no. 24, p. 6732-6741, 2000. https://doi.org/10.1093/emboj/19.24.6732
[3] J. Timmins, R. Ruigrok, & W. Weissenhorn, "Structural studies on the ebola virus matrix protein vp40 indicate that matrix proteins of enveloped rna viruses are analogues but not homologues", Fems Microbiology Letters, vol. 233, no. 2, p. 179-186, 2004. https://doi.org/10.1016/j.femsle.2004.03.002
[4] R. Ghildyal, J. Mills, M. Murray, N. Vardaxis, & J. Meanger, "Respiratory syncytial virus matrix protein associates with nucleocapsids in infected cells", Journal of General Virology, vol. 83, no. 4, p. 753-757, 2002. https://doi.org/10.1099/0022-1317-83-4-753
[5] Y. Kimura, F. Sakai, O. Nakano, O. Kisaki, H. Sugimoto, T. Sawamuraet al., "The newly identified human nuclear protein nxp-2 possesses three distinct domains, the nuclear matrix-binding, rna-binding, and coiled-coil domains", Journal of Biological Chemistry, vol. 277, no. 23, p. 20611-20617, 2002. https://doi.org/10.1074/jbc.m201440200
[6] K. Staines, V. MacRae, & C. Farquharson, "The importance of the sibling family of proteins on skeletal mineralisation and bone remodelling", Journal of Endocrinology, vol. 214, no. 3, p. 241-255, 2012. https://doi.org/10.1530/joe-12-0143
[7] K. Trinh, S. Julovi, & N. Rogers, "The role of matrix proteins in cardiac pathology", International Journal of Molecular Sciences, vol. 23, no. 3, p. 1338, 2022. https://doi.org/10.3390/ijms23031338
There are currently no reviews for this product.
KEGG: vg:2799938